At Xoligo Biologics, we specialize in nucleic acid therapeutics—mRNA, oligonucleotides, and gene editing tools—providing the agility and technical depth that early-stage innovators need. Unlike generalist CDMOs, we focus with intent, delivering boutique precision while also offering microbial fermentation expertise as a natural complement to our RNA platform. Together, these capabilities provide a true end-to-end pathway: from microbial fermentation to RNA synthesis, characterization, and GMP production.

Oligonucleotide Development

Every therapeutic starts with a strand. We deliver custom oligonucleotides with the precision, modifications, and quality required at every stage of development.

• Discovery & Preclinical – Custom primers, antisense oligos, siRNA, aptamers, and CRISPR components, available in mg-to-gram scales.
• Advanced Modifications – Phosphorothioates, 2’-OMe, locked nucleic acids (LNA), GalNAc conjugates, PEG linkers, and other chemistries tailored to client needs.
• Quality First – HPLC, LC-MS, and PAGE purification to ensure the highest standards of integrity and performance.

Whether for basic research or IND-enabling studies, our oligo services ensure clients accelerate confidently into the next stage of their program.

mRNA & Nucleic Acid Therapeutics

mRNA has moved far beyond vaccines—it now underpins cancer immunotherapies, rare disease treatments, and protein replacement strategies. Xoligo delivers the nucleic acid foundation for this new era.

• In Vitro Transcription (IVT) – Flexible platforms for mRNA, saRNA, circRNA, and DNA templates.
• Plasmid-to-RNA Workflows – Integration of microbial plasmid precursors with RNA synthesis pipelines.
• Scalable Systems – From microgram-scale discovery lots to gram-scale clinical supply.
• Future-Ready – Lipid nanoparticle (LNP) formulation capabilities in development to support RNA delivery platforms.

We provide tailored nucleic acid solutions that reduce time to clinic without compromising on quality.

CRISPR & Gene Editing Support

Gene editing tools demand precision and reproducibility. Xoligo supports innovators with the complete suite of CRISPR-associated RNA products.

• Custom gRNAs – Designed, synthesized, and QC-validated for single-gene or multiplex editing strategies.
• RNA Libraries – Scalable synthesis of pooled gRNA libraries for discovery and screening.
• Enzyme Integration – Access to Cas variants and nucleases, with microbial co-expression where required.
• QC & Analytics – Functional validation assays to ensure editing performance and reliability.

From academic discovery to therapeutic genome editing programs, we enable the next wave of genetic engineering.

Analytical & Characterization Services

Rigorous analytics are as critical as the molecules themselves. We provide advanced methods that deliver insights into structure, stability, and function.

• Structural Confirmation – LC-MS/MS and NMR-based analysis.
• Impurity Profiling – Identification and quantification of synthesis byproducts and contaminants.
• Stability & Stress Testing – Real-time, accelerated, and forced degradation studies.
• Functional Assays – Customized assays to measure biological activity in relevant systems.

Every dataset we generate is designed to support regulatory submissions, investor diligence, and internal decision-making.

GMP Manufacturing

Clinical readiness requires more than synthesis—it demands compliance, documentation, and reproducibility.

• Oligonucleotides Under GMP – Phase I–II production in gram-to-multi-gram lots.
• mRNA GMP Supply – Process development through to clinical material with validated workflows.
• Regulatory Support – IND-enabling documentation, CMC packages, and batch traceability.
• Scalability – Systems designed to scale with your program from early clinical to commercial supply.

We bring boutique responsiveness to GMP manufacturing, helping clients reach the clinic faster and safer.

Microbial Fermentation

Nucleic acid therapeutics often rely on microbial foundations. Our fermentation capabilities extend your programs from DNA templates to enzymes and proteins critical to modern biologics.

• Plasmid DNA Fermentation – High-yield E. coli plasmids as templates for RNA synthesis.
• Enzyme Production – Polymerases, ligases, and other enzymes essential for nucleic acid workflows.
• Protein & Capsid Expression – Microbial systems for capsid proteins, exosomes, and vaccine scaffolds.
• Specialty Fermentation – Tailored production for diagnostic enzymes, probiotics, and niche biologics.

Our microbial platform is designed to complement nucleic acid workstreams, ensuring seamless support whether you need plasmids, enzymes, or novel microbial expression.

Integrated End-to-End Solutions

What sets us apart is not just our expertise, but our structure.

• Specialists with Range – Nucleic acids and microbial fermentation delivered under one roof.
• Agile & Focused – Unlike large generalist CDMOs, we concentrate where innovation is most urgent.
• Seamless Tech Transfer – From plasmid fermentation to RNA synthesis, clients never leave our orbit.
• Global Readiness – Support for clients across North America, Europe, and emerging markets.

Our integrated model ensures that whether you’re building an RNA therapeutic, a CRISPR tool, or a microbial-based product, you have a partner who can take you from concept to clinic with elegance and efficiency.