At Xoligo Biologics, we believe every therapeutic begins with a strand. Oligonucleotides are the foundation of modern drug discovery, from antisense and siRNA to CRISPR guide RNAs and diagnostic probes. Our oligonucleotide development platform is designed to deliver precision, speed, and reliability at every stage of your program—whether you need milligram-scale research lots or multi-gram quantities for IND-enabling studies.
Discovery & Preclinical Oligos
Early-stage programs demand agility without sacrificing quality. We provide custom oligonucleotides tailored to discovery and preclinical needs, enabling faster decision-making and cleaner data.
- Custom Primers & Probes – For qPCR, NGS workflows, and molecular diagnostics.
- Antisense Oligonucleotides (ASOs) – Backbone-modified designs to optimize binding affinity and stability.
- siRNA Duplexes & Aptamers – Ready for gene knockdown, functional studies, or therapeutic exploration.
- CRISPR Components – High-quality gRNAs for genome editing libraries and targeted applications.
We supply material at mg-to-gram scales, giving researchers the flexibility to move from bench to preclinical animal studies with continuity of supply.
Advanced Modifications
Therapeutic oligonucleotides often require complex chemical architectures to maximize efficacy and reduce degradation. Our chemistry capabilities include:
- Backbone Modifications – Phosphorothioates, phosphorodiamidates, and mixed-linkage structures.
- Sugar Modifications – 2’-O-methyl, 2’-fluoro, locked nucleic acids (LNA) for enhanced affinity and nuclease resistance.
- Conjugates – GalNAc for liver targeting, PEG linkers, lipophilic conjugates, and custom moieties.
- Hybrid Designs – Chimeric oligos, gapmers, and multi-modified structures for advanced therapeutic strategies.
These modifications are delivered with full analytical characterization, ensuring you receive not only the molecule but the data to support its use.
Quality First
Reproducibility and purity are non-negotiable in oligonucleotide development. Our platform integrates advanced purification and analytical tools to ensure confidence at every stage.
- Purification – HPLC (reverse-phase, ion exchange) and PAGE for high-fidelity separation.
- Mass Confirmation – LC-MS/MS for molecular weight and sequence validation.
- Impurity Profiling – Quantification of synthesis byproducts and residual protecting groups.
- Documentation – Full analytical packages to support regulatory filings or internal QA systems.
We aim not only to meet specifications but to set a higher bar for quality in boutique oligo development.
Accelerating Your Path to Clinic
Our approach to oligonucleotide development is simple: remove bottlenecks, reduce risk, and deliver molecules that perform. Whether you are designing a new CRISPR library, advancing an siRNA therapeutic, or scaling antisense oligos for IND-enabling studies, Xoligo Biologics provides the technical expertise and infrastructure to accelerate your program.
By combining flexible scales, advanced chemistries, and rigorous analytics, we ensure your discovery ideas translate into real therapeutic opportunities—faster, safer, and with fewer compromises.