At Xoligo Biologics, we view nucleic acids as the new frontier of medicine. From mRNA vaccines to saRNA cancer immunotherapies, circRNA therapeutics, and plasmid DNA backbones, these modalities are reshaping the therapeutic landscape. Our mission is to provide end-to-end nucleic acid development services with the speed, customization, and scientific rigor that early-stage biotech companies need most.

mRNA Development & In Vitro Transcription

We offer a flexible, scalable platform for generating high-quality messenger RNA for discovery through clinical supply.

• Templates & Enzymes – Plasmid DNA templates and optimized polymerases for robust transcription.
• Variants – Conventional mRNA, self-amplifying RNA (saRNA), and circular RNA (circRNA).
• Capping & Tailoring – Enzymatic capping, poly(A) tailing, and custom untranslated region (UTR) designs to optimize translation efficiency.
• Scales – Microgram discovery lots to multi-gram preclinical and IND-enabling studies.

We design each process with reproducibility and downstream scale-up in mind, so your early successes translate smoothly into GMP manufacturing.

DNA & Plasmid Integration

Every RNA program begins with DNA. Our microbial fermentation and plasmid workflows provide the backbone for high-quality RNA production.

• High-Yield Plasmid DNA – E. coli fermentation with stringent QC.
• Backbone Design – Multiple promoters and regulatory elements optimized for transcription efficiency.
• Endotoxin Control – Rigorous purification to ensure suitability for in vitro or in vivo applications.
• Transition Ready – Seamless integration with our IVT systems for rapid RNA conversion.

By aligning plasmid generation and RNA synthesis under one roof, we shorten timelines and reduce the risk of inconsistencies across vendors.

Therapeutic Applications

Our nucleic acid services are designed for the most impactful next-generation therapies.

• mRNA Vaccines – Infectious disease and pandemic response platforms.
• Cancer Immunotherapies – Personalized mRNA and saRNA vaccines targeting neoantigens.
• Protein Replacement – mRNA as a delivery vehicle for rare disease and metabolic disorders.
• CRISPR & Gene Editing – gRNAs and mRNA-encoded nucleases for cutting-edge editing systems.

By combining flexible design, advanced chemistry, and rigorous analytics, we help you move from concept to clinic in record time.

Analytical & Quality Support

Every strand of RNA we produce is fully characterized to meet the highest quality standards.

• Identity & Purity – HPLC, capillary electrophoresis, and LC-MS confirmation.
• Integrity & Stability – Stress testing and accelerated degradation analysis.
• Functional Validation – In vitro translation assays to confirm biological activity.
• Documentation – Full release and characterization reports to support regulatory filings.

Future-Ready Capabilities

The field is evolving rapidly—and so are we. We are actively expanding into lipid nanoparticle (LNP) formulation and advanced delivery systems, creating a streamlined path from synthesis to functional drug product.

Your Partner in Nucleic Acid Innovation

At Xoligo Biologics, we combine boutique focus with scientific breadth, giving clients a one-stop partner for nucleic acid therapeutics. Whether your goal is a next-gen mRNA vaccine, a rare disease therapeutic, or a CRISPR-enabled editing system, our platform ensures speed, quality, and scalability at every step.

With Xoligo, you can accelerate your nucleic acid program into the clinic with confidence.