At Xoligo Biologics, we provide the RNA and enzyme components that power modern genome editing. From CRISPR guide RNAs to nuclease co-expression, our services are built to give developers the precision, scalability, and reproducibility needed to advance editing technologies into research and clinical applications.

We understand that gene editing projects require not only custom synthesis, but also rigorous validation and flexible design. Our platform ensures that every molecule we deliver is engineered to perform with the highest fidelity and consistency.

Custom gRNAs

The success of CRISPR programs begins with guide RNA design and production.

• Single & Multiplex Guides – Synthesized with high accuracy for individual targets or pooled applications.
• Scalable Output – From small pilot runs to multi-gram lots supporting in vivo studies.
• Sequence Optimization – Designed for minimal off-target activity and maximum editing efficiency.
• Delivery-Ready – Compatible with lipid nanoparticles, electroporation, or viral vector systems.

RNA Libraries

Discovery and screening require throughput. Our library services enable rapid exploration of genetic landscapes.

• Pooled gRNA Libraries – High-diversity libraries for functional genomics, knockout screens, and pathway discovery.
• Custom Panels – Targeted sets for focused gene families or disease pathways.
• QC-Validated – Library integrity confirmed with sequencing and bioinformatics analysis.

Enzyme & Cas Variant Integration

Beyond guide RNAs, CRISPR platforms depend on enzymes—Cas nucleases and beyond.

• Cas9, Cas12, Cas13 Variants – Access to diverse nucleases for DNA and RNA editing.
• Enzyme Expression – Microbial expression systems for nucleases and accessory proteins.
• Co-Delivery – Streamlined workflows pairing gRNAs with their corresponding nucleases.
• Future Expansion – Support for next-generation base editors and prime editing systems.

Analytical & QC Services

Gene editing demands proof, not assumption. We provide data-driven validation at every step.

• Mass & Sequence Confirmation – LC-MS and sequencing to ensure integrity.
• Purity Analysis – HPLC-based profiling of guide RNAs and enzymes.
• Functional Assays – In vitro cleavage and editing efficiency studies.
• Stability Testing – Shelf-life and stress studies to support long-term program planning.

Applications We Support

• Therapeutics – IND-enabling CRISPR-based therapies for rare diseases, oncology, and metabolic disorders.
• Research & Discovery – High-throughput functional genomics for target validation.
• Agricultural & Industrial – Genome editing tools for crop engineering, enzyme optimization, and microbial strain design.

Partnering for Precision

CRISPR is moving rapidly from concept to clinic. At Xoligo Biologics, we act as a specialized partner for RNA and enzyme components, ensuring that your editing programs are supported by molecules of the highest quality.

With custom synthesis, scalable production, and robust analytics, we give you the confidence to move forward—whether you’re advancing a therapeutic pipeline or building the next-generation genome editing toolkit.